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The clinical trials that demonstrated impressive weight loss results (mean 1015% body weight reduction at 6 months in Phase 2 studies) had dropout rates of 1520% specifically due to GI side effects

What specific benefits have preclinical studies observed for each compound in models of metabolic disease

In humans, a RCT enrolling 156 patients with a BMI 27 kg/m 2 failed to demonstrate that one year of liraglutide treatment could improve pain in patients with KOA compared to placebo, despite a significant BW difference of approximately 4 kg at end of study 105

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